Principal Bioinformatician / Computational Biologist, Drug Safety

Help build the future of drug safety monitoring Drug-induced toxicity remains one of the biggest causes of drug-development delay, clinical failure and patient harm. Current monitoring is often insensitive, organ-specific and reliant on damage becoming clinically apparent. We think there is a better way. Tagomics is a Cambridge-based biotechnology company developing a next-generation multi-omic biomarker platform. Originating from pioneering research by Dr Robert Neely and colleagues at the University of Birmingham, our proprietary technology captures epigenetic features from circulating cell-free DNA that, when combined with advanced bioinformatics, let us detect and localise tissue injury across multiple organs, giving drug developers earlier and more biologically precise insight into treatment-related toxicity. With successful proof-of-concept programmes behind us and pharmaceutical partners already engaged, we are building towards our first commercial products at Babraham Research Campus. Read Our Recent Scientific Paper https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00223-1 The role This is a hands-on principal scientist role, not a management-only role. You will spend most of your time (around 70%) doing the science yourself: developing methods, writing code and working directly with the data. The rest of your time will be working with partners, team leadership and technical strategy. You will be the most technically experienced bioinformatician on the drug safety programme. You will line-manage two senior bioinformaticians who are already strong practitioners, so we need someone with the depth to review their methods, support their technical development, and be someone they can bring difficult problems to. You will also be key to our work with pharmaceutical partners. That means helping to design studies with them, explaining what the data can and can't tell them, and presenting results in a way that supports their decisions. What You'll Be Doing Do the science Develop, build and evaluate novel computational methods for epigenetic markers from cell-free DNAAdapt or write bioinformatics software alongside our software engineering team where existing tools fall shortDrive toxicity biomarker discovery and refinementTranslate findings into outputs partners can act on Set the analytical direction Lead computational strategy independently, translating programme objectives into bioinformatics/analytical prioritiesShape experimental designs (considering power/sample size, batch effects etc.), and plan appropriate controlsCollaborate on long-term assay and product development Work with partners Contribute to technical discussions with pharmaceutical and biotech partners, from study scoping through to resultsPresent findings to partner scientists and decision-makers alongside our Programme LeadHelp turn partner questions into well-designed studies and analyses Lead and develop the team Lead, coach and technically challenge two senior bioinformaticiansSet standards for methods, code quality and reproducibility across the programmeContribute to publications, IP and conference presentations Essential What we're looking for PhD in bioinformatics, computational biology, or related fields, followed by substantial experience (8+ years) in industry or academiaCurrent, hands-on coding expertise in Python and/or R. You should still be writing substantial analytical code in your current roleIn-depth knowledge of at least one omics technologyA track record of developing new computational methodsExperience applying statistical modelling or machine-learning methods to complex biological datasetsProven ability to set computational strategy and manage projects independently Experience developing the technical skills of other bioinformaticiansExperience working with external partners, customers or collaborators in a commercial setting Nice-to-have Python as your main languageKnowledge of liquid biopsy, clinical studies or the drug development life cyclePrevious line management experienceExperience analysing epigenetic and/or transcriptomic datasets (e.g. MeDIP-seq, ATAC-seq, ChIP-seq, WGBS, RNA-seq)Knowledge of software engineering best practices: testing, code review, version controlExperience in multi-disciplinary teams, including with laboratory membersStartup, biotech or pharma experience Who You Are You love solving problems and getting your hands dirty fixing them, alongside your teamYou can explain a complex result at the right level for your audience, from a five-minute summary for a commercial partner to a deep technical discussion with a bioinformaticianYou want to work on a brand-new technology that can change how drug toxicity is detected and monitored, with all the challenges that brings Our hiring process Online screening call: your experience, goals and questions about the roleOnline technical interview: technical questions and a presentation of a take-home bioinformatics challenge, where we can see how you might tackle a problem. We expect this would take up to 3 hours to prepare.In-person team interview: meet leadership and your future colleagues What We Offer Competitive salaryShare option schemeMatched pension contributions up to 8%Private healthcare with AvivaPerformance-related bonus schemeFlexible hybrid working (minimum 2 days per week on-site)25 days holiday plus bank holidays, and a discretionary 3-day Christmas shutdown We're based at Babraham Research Campus, one of Europe's leading life-science hubs, with modern accessible offices, on-site parking, a gym, restaurant and countryside on the doorstep. We are not currently able to sponsor visas for this role. Applicants must have the right to work in the UK. No agencies please. Tagomics is committed to building a diverse and inclusive team.